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AMINO ACIDS FUNCTIONALIZED HETEROGENEOUS CHIRAL CATALYST amino acids functionalized heterogeneous chiral catalyst AMINO ACIDS FUNCTIONALIZED HETEROGENEOUS CHIRAL CATALYST amino acids functionalized heterogeneous chiral catalyst

AMINO ACIDS FUNCTIONALIZED HETEROGENEOUS CHIRAL CATALYST

Heterogeneous asymmetric catalysis remains as an exciting research field in chiral catalysis since the heterogeneous catalyst can be separated easily from the reaction mixture compare to conventional homogeneous catalyst. The aim of the research is to develop and investigate a novel heterogeneous asymmetric catalyst using amino acid as chiral promoter. The catalysts were synthesized by attachment of amino acids such as L-glutamic acid, L-leucine and L-phenylalanine onto the hydrophilic part of hydrolyzed octadecyltrichlorosilane (OTS). The amino acidhydrolyzed OTS materials were used as catalysts for the asymmetric hydration of epoxycyclohexene to yield two diastereoisomers, namely (1R,2R)-trans-1,2-cyclohexanediol, (1S,2S)-trans-1,2-cyclohexanediol and cis-1,2-cyclohexanediol.

Heterogeneous and Homogeneous Chiral Catalysts amino acids functionalized heterogeneous chiral catalyst Heterogeneous and Homogeneous Chiral Catalysts amino acids functionalized heterogeneous chiral catalyst

Heterogeneous and Homogeneous Chiral Catalysts

The work embodied in this book comprises of brief introduction of chiral homogeneous and heterogeneous asymmetric catalysis. Research work presented in this book presents synthesis and physicochemical characterization of mesoporous materials MCM-41 and SBA-15 and used them as supports for immobilization of chiral BINOL, immobilization of chiral BINOL on mesoporous materials SBA-15 and MCF of relatively large pore size and used as active catalysts for asymmetric diethylzinc addition to aldehydes, synthesis of chiral recyclable salen based metal complexes, new chiral polymeric Zn(salen) catalyst and used as a heterogeneous catalyst in asymmetric phenylacetylene addition to carbonyls, synthesis of chiral dimeric and polymeric Mn(III) salen complexes respectively. These complexes were used as recyclable catalysts in oxidative kinetic resolution of racemic secondary alcohols.

Asymmetric Homogeneous and Heterogeneous Catalysts amino acids functionalized heterogeneous chiral catalyst Asymmetric Homogeneous and Heterogeneous Catalysts amino acids functionalized heterogeneous chiral catalyst

Asymmetric Homogeneous and Heterogeneous Catalysts

The work embodied in this book comprises of brief introduction of chiral catalysis under the homogenous and heterogeneous reaction condition. Synthesis and characterization of mesoporous material MCM-41 and SBA-15 and used them as a support for heterogenization of chiral Mn(III) salen complexes. Dicationic MnIII Salen Complex Exchanged in the Inter-layers of Montmorillonite Clay. This homogeneous and heterogenous catalyst used as active catalysts for the synthesis of chiral epoxides of non-functionalized alkenes. The epoxide functional group is one of the most useful intermediates in organic synthesis. Epoxides are versatile products and they easily undergo stereo specific ring opening reaction to form bifunctional compounds, which are very important chiral building blocks used in the preparation of optically pure bioactive molecules.

Macrocyclic glycopeptide-based chiral stationary phases amino acids functionalized heterogeneous chiral catalyst Macrocyclic glycopeptide-based chiral stationary phases amino acids functionalized heterogeneous chiral catalyst

Macrocyclic glycopeptide-based chiral stationary phases

This review summarizes the chiral high performance liquid chromatographic (HPLC) direct methods with different class of macrocyclic antibiotics as chiral selectors. In the past few decades, these organic macromolecules have become one of the most useful chiral selectors in analytical HPLC, thin layer chromatography (TLC) and capillary electrophoresis (CE) methods and also in preparative methods. The macrocyclic glicopeptides, such as teicoplanin, vancomycin and ristocetin, seem to be the most useful selectors for the enantioseparation of compounds with primer amino groups. Especially in wild range of amino acids and proteins. In this work the physicochemical properties, the efficiency of these antibiotics and the mechanism of separation were discussed in reversed phase (RPM), polar organic and ionic mode (POM, PIM) and in normal phase system (NPM).

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis amino acids functionalized heterogeneous chiral catalyst Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis amino acids functionalized heterogeneous chiral catalyst

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis

This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Synthesis of Branched Amino Polyols and Amino Hydroxy Acids amino acids functionalized heterogeneous chiral catalyst Synthesis of Branched Amino Polyols and Amino Hydroxy Acids amino acids functionalized heterogeneous chiral catalyst

Synthesis of Branched Amino Polyols and Amino Hydroxy Acids

The main aim of this work is the development of synthetic routes towards amino alcohols as well as branched ?? and ??amino acids starting from achiral and chiral (racemic and optically active) isoxazolines and N-methylisoxazolinium salts. The isoxazolines were treated with a variety of Grignard reagents and organolithium complexes as C-nucleophiles. These results were comparable to the findings of analog additions to the ‘’activated’’ isoxazolines, that is, to the isoxazolinium salts. The latter react smoothly with Grignard reagents, as well as with weaker C-nucleophiles such as sodium diethyl malonate or lithium ester enolate. At the same time it was observed, that the addition proceeds with -particly- good diastereoselectivity under mild reaction conditions, leading to good yields of the corresponding substituted isoxazolidines.

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry amino acids functionalized heterogeneous chiral catalyst Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry amino acids functionalized heterogeneous chiral catalyst

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Building Blocks, Catalysis and Coupling Chemistry

This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides amino acids functionalized heterogeneous chiral catalyst Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides amino acids functionalized heterogeneous chiral catalyst

Andrew Hughes B. Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides

This is the last of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides Volume 5 of this series presents a wealth of methods to analyze amino acids and peptides. Classical approaches are described, such as X-ray analysis, chromatographic methods, NMR, AFM, mass spectrometry and 2D-gel electrophoresis, as well as newer approaches, including Surface Plasmon Resonance and array technologies. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Chiral Amino Alcohol based Schiff base Complexes amino acids functionalized heterogeneous chiral catalyst Chiral Amino Alcohol based Schiff base Complexes amino acids functionalized heterogeneous chiral catalyst

Chiral Amino Alcohol based Schiff base Complexes

This work reports some original and significant contributions on chiral coordination complexes. Complexes of chiral amino alcohols based Schiff base ligands with biologically and catalytically important metal ions have been developed and studied with respect to their structural, spectroscopic, supramolecular and catalytic properties. The importance of chiral amino alcohol based Schiff base ligands in coordination chemistry is briefly discussed in the introduction chapter. Synthetic details and spectroscopic characterization data of some new chiral Schiff base ligands and their metal complexes are presented in chapter two. Detailed studies on a series of biologically and catalytically relevant chiral Mn(IV) complexes form the content of the third chapter. A series of interesting mixed valence multinuclear cobalt complexes of chiral amino alcohol based ligands has been described in chapter four. Studies on some chiral copper complexes highlighting their structural and supramolecular properties are presented in fifth chapter. Finally, the work is concluded giving an overall summary as the sixth chapter.

Enantioresolution of certain pharmaceuticals by liquid chromatography amino acids functionalized heterogeneous chiral catalyst Enantioresolution of certain pharmaceuticals by liquid chromatography amino acids functionalized heterogeneous chiral catalyst

Enantioresolution of certain pharmaceuticals by liquid chromatography

Enantioresolution of pharmaceuticals and biologically important compounds continues to be important and challenging task in academia and industry. Sensitive, cost-effective and reproducible methods are reported for chiral separation of such compounds, namely (R,S)-mexiletine, (R,S)-baclofen, ?-blockers (i.e., (R,S)-atenolol, (R,S)-propranolol, (R,S)-bisoprolol, (R,S)-metoprolol and (R,S)-carvedilol), DL-amino acids (both proteinogenic and non-proteinogenic) and certain chiral aldehydes and ketones. Indirect approach of enantioresolution offers several advantages in comparison to direct approach. These include possibility of synthesis of chiral derivatizing reagents (CDRs) that could react easily with the functional group of the analyte, availability of certain CDRs commercially, excellent separation and detection possibilities of the resulting diastereomers, easy optimization of chromatographic conditions, and the prospect of using relatively inexpensive achiral columns. Cyanuric chloride and 1,5-Di?uoro-2,4-dinitrobenzene serve as excellent structural platforms to synthesize a wide spectrum of CDRs by using amino acids and their amides as chiral auxiliaries.

Switching From Homogeneous To Heterogeneous Catalysis amino acids functionalized heterogeneous chiral catalyst Switching From Homogeneous To Heterogeneous Catalysis amino acids functionalized heterogeneous chiral catalyst

Switching From Homogeneous To Heterogeneous Catalysis

Direct aldol reactions have been successfully performed using aromatic aldehyde and cyclic ketone in nonpolar/polar solvent using immobilized picolylamine on zirconia as a catalyst, in a double walled three necked batch reactor. The prepared catalyst was characterized by SEM, XRD and FT-IR. FT-IR peaks reveal the presence of picolylamine on the surface of zirconia. The catalyst show excellent catalytic activity in aldol reaction of cyclohexanone with benzaldehyde in cyclohexane giving (2-hydroxy phenyl methyl cyclohexanone) (55.7% yields) in 4 hours at 80°C. Furthermore, the catalyst is recoverable by simple filtration and could be used several times without significant loss in activity. In addition the chiral amine will be anchor on the surface of zirconia for asymmetric aldol reaction in future studies.

QNT Аминокислоты 3000, 300 таблеток amino acids functionalized heterogeneous chiral catalyst QNT Аминокислоты 3000, 300 таблеток amino acids functionalized heterogeneous chiral catalyst

QNT Аминокислоты 3000, 300 таблеток

В совокупности с занятиями спортом, Amino Acids 3000 - идеальное средство для безупречной мускулатуры. Полученные из молочного альбумина, они состоят из 20-и аминокислот, включая аминокислоты с разветвленными цепями. Amino Acids 3000 гарантирует спортсменам безупречный баланс незаменимых аминокислот.

Multicomponent One Pot Green Synthesis of 1, 5-Benzodiazepines amino acids functionalized heterogeneous chiral catalyst Multicomponent One Pot Green Synthesis of 1, 5-Benzodiazepines amino acids functionalized heterogeneous chiral catalyst

Multicomponent One Pot Green Synthesis of 1, 5-Benzodiazepines

Multicomponent Reactions (MCRs) are a promising and vital field of green chemistry. Benzodiazepines are widely used class of bioactive compounds due to their remarkable biological and pharmacological properties. However, many of the methods of synthesis of benzodiazepines suffer major or minor limitations like tedious work up procedure, applications of expensive and hazardous catalyst, long reaction times, unsatisfactory yields, require separation of the catalyst from the product and formation of side products. In our project, we have reviewed the various heterogenous and homogenous catalysts utilized for the synthesis of 1, 5-benzodizepines in the last decade and explored the novel, non-expensive, easily available, non toxic catalyst for the efficient synthesis of 1,5-benzodiazepines under solvent-free conditions. The catalytic efficiency of various acids studied, are categorized in four categories with their proposed mechanism of actions: Amino acids, Aliphatic acids, Aromatic acids and Miscellaneous acids. The remarkable features of these new acid catalysts are high yield, short reaction times, cleaner reaction profiles and high regioselectivity.

David A. Bender Amino Acid Metabolism amino acids functionalized heterogeneous chiral catalyst David A. Bender Amino Acid Metabolism amino acids functionalized heterogeneous chiral catalyst

David A. Bender Amino Acid Metabolism

Amino Acid Metabolism, 3rd Edition covers all aspects of the biochemistry and nutritional biochemistry of the amino acids. Starting with an overview of nitrogen fixation and the incorporation of inorganic nitrogen into amino acids, the book then details other major nitrogenous compounds in micro-organisms, plants and animals. Contents include a discussion of the catabolism of amino acids and other nitrogenous compounds in animals, and the microbiological reactions involved in release of nitrogen gas back into the atmosphere. Mammalian (mainly human) protein and amino acid requirements are considered in detail, and the methods that are used to determine them. Chapters consider individual amino acids, grouped according to their metabolic origin, and discussing their biosynthesis (in plants and micro-organisms for those that are dietary essentials for human beings), major metabolic roles (mainly in human metabolism) and catabolism (again mainly in human metabolism). There is also discussion of regulatory mechanisms for all these metabolic pathways, and of metabolic and genetic diseases affecting the (human) metabolism of amino acids. Throughout the book the emphasis is on the nutritional importance of amino acids, integration and control of metabolism and metabolic and other disturbances of relevance to human biochemistry and health. Completely revised edition of this comprehensive text covering all the latest findings in amino acid metabolism research Written by an authority in the field Covers new advances in structural biology Clear illustrations of all structures and metabolic pathways Full list of recommended further reading for each chapter and bibliography of papers cited in the text

Amino acid production by utilizing indigenous substrates amino acids functionalized heterogeneous chiral catalyst Amino acid production by utilizing indigenous substrates amino acids functionalized heterogeneous chiral catalyst

Amino acid production by utilizing indigenous substrates

During the last two decades, fermentation process was getting more attention for the production of amino acids. It mainly revolves around production of essential amino acids which cannot synthesize by human. Present project was also based on isolation and screening of twenty one bacterial isolates from soil and water and tested their potential to ferment different media for the production of different amino acids. However, the main emphasis was given to isoleucine. As a whole, fifteen isolates produced isoleucine i.e., 70.0% while six appeared to be non – producers for isoleucine. Out of eleven isolates obtained from soil, eight were producers and three non producers displaying 72.0% production level. This percentage remained almost the same in bacteria obtained from water.

Enzyme Catalytic Residues amino acids functionalized heterogeneous chiral catalyst Enzyme Catalytic Residues amino acids functionalized heterogeneous chiral catalyst

Enzyme Catalytic Residues

Enzyme's active site sequence is crucial to execute its functions. Enzymes of different origin have distinct preference of charged and polar amino acids at their active site. Certainly high probability occurrence of these amino acids does not indicate their conservation at the active site. The knowledge of amino acid frequency distribution at the active site can be exploited in designing novel enzyme's active site as well as their specific inhibitors.

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